| 1 | Guatemala City , Guatemala | 994,938 | 14.641 / -90.513 |
| 2 | Villa Nueva , Guatemala | 618,397 | 14.525 / -90.585 |
| 3 | Mixco , Guatemala | 465,773 | 14.631 / -90.607 |
| 4 | Cobán , Alta Verapaz | 212,047 | 15.470 / -90.375 |
| 5 | Quetzaltenango , Quetzaltenango | 180,706 | 14.845 / -91.523 |
| 6 | Jalapa , Jalapa | 159,840 | 14.635 / -89.991 |
| 7 | Escuintla , Escuintla | 156,313 | 14.301 / -90.788 |
| 8 | Villa Canales , Guatemala | 155,423 | 14.483 / -90.534 |
| 9 | Jutiapa , Jutiapa | 145,880 | 14.285 / -89.888 |
| 10 | Chichicastenango , El Quiche | 141,567 | 14.943 / -91.111 |
| 11 | San Juan Sacatepéquez , Guatemala | 136,886 | 14.719 / -90.644 |
| 12 | Petapa , Guatemala | 135,447 | 14.502 / -90.562 |