| Name | Population | Latitude/Longitude |
| 1 | Managua , Managua Department |
973,087 |
12.133 / -86.25 |
| 2 | León , León Department |
144,538 |
12.435 / -86.879 |
| 3 | Masaya , Masaya Department |
130,113 |
11.973 / -86.096 |
| 4 | Chinandega , Chinandega Department |
126,387 |
12.63 / -87.131 |
| 5 | Matagalpa , Matagalpa Department |
109,089 |
12.928 / -85.919 |
| 6 | Estelí , Estelí Department |
96,422 |
13.093 / -86.356 |
| 7 | Granada , Granada Department |
89,409 |
11.931 / -85.954 |
| 8 | Mateare , Managua Department |
61,234 |
12.235 / -86.428 |
| 9 | Jinotega , Jinotega Department |
55,000 |
13.091 / -86.002 |
| 10 | El Viejo , Chinandega Department |
53,504 |
12.663 / -87.167 |
| 11 | Nueva Guinea , South Caribbean Coast |
52,929 |
11.688 / -84.456 |
| 12 | Ciudad Sandino, Managua Department |
50,000 |
12.159 / -86.344 |