| Name | Population | Latitude/Longitude |
| 1 | Guatemala City , Guatemala |
994,938 |
14.641 / -90.513 |
| 2 | Villa Nueva , Guatemala |
618,397 |
14.525 / -90.585 |
| 3 | Mixco , Guatemala |
465,773 |
14.631 / -90.607 |
| 4 | Cobán , Alta Verapaz |
212,047 |
15.47 / -90.375 |
| 5 | Quetzaltenango , Quetzaltenango |
180,706 |
14.845 / -91.523 |
| 6 | Jalapa , Jalapa |
159,840 |
14.635 / -89.991 |
| 7 | Escuintla , Escuintla |
156,313 |
14.301 / -90.788 |
| 8 | Villa Canales , Guatemala |
155,423 |
14.483 / -90.534 |
| 9 | Jutiapa , Jutiapa |
145,880 |
14.285 / -89.888 |
| 10 | Chichicastenango , Quiché |
141,567 |
14.943 / -91.111 |
| 11 | San Juan Sacatepéquez , Guatemala |
136,886 |
14.719 / -90.644 |
| 12 | Petapa , Guatemala |
135,447 |
14.502 / -90.562 |