| Name | Country | Feature class | Latitude | Longitude | |
|---|---|---|---|---|---|
651  | Laguneta Sesecapa Laguna Sipacate,Laguneta Sesecapa | Guatemala, Suchitepeque | lake | N 14° 4′ 58'' | W 91° 35′ 12'' |
652  | Sipacate  Sipacate | Guatemala, Escuintla Municipio de La Gomera | populated place | N 13° 56′ 0'' | W 91° 9′ 0'' |
| 653 | Sibinal Sabinal,Sibinal,Sivinal | Guatemala, San Marcos | seat of a second-order administrative division population 1,657 | N 15° 8′ 58'' | W 92° 2′ 56'' |
| 654 | Sibilia Sibilia | Guatemala, Quetzaltenango | seat of a second-order administrative division population 1,180 | N 14° 59′ 38'' | W 91° 37′ 25'' |
| 655 | Laguneta Sepalau Laguna Sepalau,Laguneta Sepalau | Guatemala, Alta Verapaz | lake | N 15° 47′ 15'' | W 90° 12′ 39'' |
656  | Senyabá Senyaba,Senyabá,Senyeba,Senyebá | Guatemala, Totonicapán | locality | N 14° 52′ 21'' | W 91° 13′ 12'' |
| 657 | Sayaxché Sayaxche,Sayaxché,Sayazche,Sayazché | Guatemala, Petén | seat of a second-order administrative division population 9,100 | N 16° 31′ 28'' | W 90° 11′ 16'' |
| 658 | Saxche Sasche,Sasché,Saxche | Guatemala, Petén | locality | N 17° 11′ 0'' | W 89° 58′ 0'' |
| 659 | San Vicente Pacaya San Vicente,San Vicente Martir,San Vicente Mártir,San Vicente Pacaya | Guatemala, Escuintla Municipio de San Vicente Pacaya | seat of a second-order administrative division population 7,162 | N 14° 24′ 52'' | W 90° 38′ 10'' |
| 660 | Santo Domingo Xenacoj Santa Domingo Xenacoj,Santo Domingo Xecanoj,Santo Domingo Xenacoj,Xenacoj,Xenaeoj | Guatemala, Sacatepéquez | seat of a second-order administrative division population 8,791 | N 14° 40′ 50'' | W 90° 42′ 0'' |
| 661 | Santo Domingo Suchitepéquez Santo Domingo,Santo Domingo Suchitepequez,Santo Domingo Suchitepéquez | Guatemala, Suchitepeque | seat of a second-order administrative division population 6,270 | N 14° 28′ 44'' | W 91° 28′ 59'' |
| 662 | Santiago Chimaltenango Chimaltenango,Santiago Chimaltenango | Guatemala, Huehuetenango Municipio de Santiago Chimaltenango | seat of a second-order administrative division population 3,020 | N 15° 28′ 35'' | W 91° 41′ 47'' |
663  | Cerro Santiago Cerro Santiago | Guatemala, Jalapa Municipio de San Pedro Pinula | mountain elevation 1192m | N 14° 45′ 14'' | W 89° 51′ 50'' |
| 664 | Santa Sofía Hacienda Santa Sofia,Santa Sofia,Santa Sofía | Guatemala, Escuintla Municipio de Santa Lucía Cotzumalguapa | locality | N 14° 23′ 0'' | W 90° 59′ 0'' |
| 665 | Santa Rosa de Lima Santa Rosa,Santa Rosa de Lima,Santa Rose de Lima | Guatemala, Santa Rosa Department | seat of a second-order administrative division population 5,984 | N 14° 23′ 17'' | W 90° 17′ 44'' |
| 666 | Santa Rosita Santa Rosa,Santa Rosita | Guatemala, Petén | locality | N 16° 33′ 35'' | W 90° 37′ 48'' |
| 667 | Santa María Ixhuatán Ixhuatan,Ixhuatán,Santa Maria Ixhuatan,Santa María Ixhuatán | Guatemala, Santa Rosa Department | seat of a second-order administrative division population 3,634 | N 14° 11′ 24'' | W 90° 16′ 29'' |
| 668 | Santa María Chiquimula Santa Maria Chiquimula,Santa María Chiquimula | Guatemala, Totonicapán Municipio de Santa María Chiquimula | seat of a second-order administrative division population 6,980 | N 15° 1′ 47'' | W 91° 19′ 45'' |
| 669 | Santa Lucía Utatlán Santa Lucia,Santa Lucia Utatlan,Santa Lucía,Santa Lucía Utatlán | Guatemala, Sololá | seat of a second-order administrative division population 1,305 | N 14° 46′ 16'' | W 91° 16′ 1'' |
| 670 | Santa Lucia La Reforma Santa Lucia La Reforma,Santa Lucía La Reforma | Guatemala, Totonicapán | seat of a second-order administrative division population 1,406 | N 15° 7′ 41'' | W 91° 14′ 10'' |
| 671 | Laguna Santa Isabel Laguna Santa Isabel,Laguna Santa Izabel | Guatemala, Izabal Department | lake | N 15° 49′ 32'' | W 88° 28′ 28'' |
| 672 | Santa Eulalia Santa Eulalia | Guatemala, Huehuetenango San Pedro Soloma | seat of a second-order administrative division population 4,921 | N 15° 43′ 50'' | W 91° 27′ 30'' |
| 673 | Santa Elena FRS,Santa Elena | Guatemala, Petén | populated place | N 16° 55′ 4'' | W 89° 53′ 34'' |
| 674 | Santa Cruz Verapaz Santa Cruz,Santa Cruz Verapaz | Guatemala, Alta Verapaz Municipio de Santa Cruz Verapaz | seat of a second-order administrative division population 5,843 | N 15° 22′ 24'' | W 90° 25′ 42'' |
| 675 | Santa Cruz Naranjo Santa Cruz,Santa Cruz Naranjo | Guatemala, Santa Rosa Department | seat of a second-order administrative division population 6,254 | N 14° 23′ 17'' | W 90° 22′ 11'' |
| 676 | Santa Cruz Muluá Mulua,Muluá,Santa Cruz Mulua,Santa Cruz Muluá | Guatemala, Retalhuleu | seat of a second-order administrative division population 2,706 | N 14° 34′ 53'' | W 91° 37′ 27'' |
| 677 | Santa Cruz La Laguna Santa Cruz,Santa Cruz La Laguna | Guatemala, Sololá | seat of a second-order administrative division population 1,422 | N 14° 44′ 39'' | W 91° 12′ 25'' |
| 678 | Santa Cruz Balanyá Santa Cruz Balanya,Santa Cruz Balanyá | Guatemala, Chimaltenango Municipio de Santa Cruz Balanyá | seat of a second-order administrative division population 7,825 | N 14° 41′ 6'' | W 90° 55′ 8'' |
| 679 | Sierra de Santa Cruz Sierra de Santa Cruz,Sierras Santa Cruz | Guatemala, Izabal Department | mountains | N 15° 41′ 19'' | W 89° 20′ 8'' |
| 680 | Laguneta Santa Cruz Laguna Santa Cruz,Laguneta Santa Cruz | Guatemala, Petén | lake | N 17° 19′ 0'' | W 89° 48′ 0'' |
| 681 | Santa Clara La Laguna Santa Clara,Santa Clara La Laguna | Guatemala, Sololá | seat of a second-order administrative division population 5,306 | N 14° 42′ 54'' | W 91° 18′ 12'' |
| 682 | Santa Catarina Palopó Santa Catalina,Santa Catarina,Santa Catarina Palopo,Santa Catarina Palopó | Guatemala, Sololá | seat of a second-order administrative division population 2,948 | N 14° 43′ 24'' | W 91° 8′ 3'' |
| 683 | Santa Catarina Barahona Santa Catalina,Santa Catarina,Santa Catarina Barahona | Guatemala, Sacatepéquez | seat of a second-order administrative division population 3,214 | N 14° 33′ 4'' | W 90° 47′ 9'' |
| 684 | Santa Apolonia Santa Apolonia | Guatemala, Chimaltenango Municipio de Santa Apolonia | seat of a second-order administrative division population 2,396 | N 14° 47′ 25'' | W 90° 58′ 21'' |
| 685 | Santa Ana Huista Santa Ana Huista | Guatemala, Huehuetenango Municipio de Santa Ana Huista | seat of a second-order administrative division population 2,004 | N 15° 40′ 51'' | W 91° 49′ 12'' |
| 686 | Santa Ana Santa Ana | Guatemala, Petén Municipio de Santa Ana | seat of a second-order administrative division population 9,523 | N 16° 48′ 20'' | W 89° 49′ 37'' |
| 687 | San Sebastián Huehuetenango San Sebastian,San Sebastian Huehuetenango,San Sebastián,San Sebastián Huehuetenango | Guatemala, Huehuetenango Municipio de San Sebastián Huehuetenango | seat of a second-order administrative division population 1,311 | N 15° 23′ 15'' | W 91° 36′ 55'' |
| 688 | Sansare Sansare | Guatemala, El Progreso Municipio de Sansare | seat of a second-order administrative division population 3,792 | N 14° 44′ 44'' | W 90° 6′ 58'' |
| 689 | San Raimundo San Raimundo,San Raymundo | Guatemala, Guatemala Municipio de San Raymundo | seat of a second-order administrative division population 8,689 | N 14° 45′ 52'' | W 90° 35′ 41'' |
| 690 | San Rafael Pie de la Cuesta San Rafael,San Rafael Pie Cuesta,San Rafael Pie de La Cuesta,San Rafael Pie de la Cuesta,San Rafael ... | Guatemala, San Marcos | seat of a second-order administrative division population 4,320 | N 14° 55′ 49'' | W 91° 54′ 50'' |
| 691 | San Rafael Petzal San Rafael,San Rafael Petzal | Guatemala, Huehuetenango Municipio de San Rafael Petzal | seat of a second-order administrative division population 1,525 | N 15° 24′ 17'' | W 91° 39′ 52'' |
| 692 | San Rafael Las Flores San Rafael,San Rafael Las Flores | Guatemala, Santa Rosa Department | seat of a second-order administrative division population 2,572 | N 14° 28′ 33'' | W 90° 10′ 42'' |
| 693 | San Rafael La Independencia San Rafael Independencia,San Rafael La Independencia | Guatemala, Huehuetenango Municipio de San Rafael La Independencia | seat of a second-order administrative division population 1,059 | N 15° 42′ 5'' | W 91° 32′ 7'' |
| 694 | San Pedro Pinula San Pedro Pinula | Guatemala, Jalapa Municipio de San Pedro Pinula | seat of a second-order administrative division population 3,302 | N 14° 39′ 48'' | W 89° 50′ 46'' |
| 695 | San Pedro Necta San Pedro Necta | Guatemala, Huehuetenango Municipio de San Pedro Necta | seat of a second-order administrative division population 3,554 | N 15° 29′ 29'' | W 91° 45′ 55'' |
| 696 | San Pédro Jocopilas San Pedro Jocopilas,San Pédro Jocopilas | Guatemala, Quiché | seat of a second-order administrative division population 1,040 | N 15° 5′ 42'' | W 91° 9′ 4'' |
| 697 | Volcán San Pedro Volcan San Pedro,Volcan de Choyjuyub,Volcán San Pedro,Volcán de Choyjuyub | Guatemala, Sololá | volcano elevation 3020m | N 14° 39′ 21'' | W 91° 15′ 57'' |
| 698 | San Pablo La Laguna San Pablo,San Pablo La Laguna,San Pablo Laguna | Guatemala, Sololá | seat of a second-order administrative division population 6,186 | N 14° 43′ 15'' | W 91° 16′ 20'' |
| 699 | San Miguel Sigüilá San Miguel Siguila,San Miguel Sigüilá,Siguila,Sigüilá | Guatemala, Quetzaltenango | seat of a second-order administrative division population 7,551 | N 14° 53′ 43'' | W 91° 36′ 52'' |
| 700 | San Miguel Panán Panan,Panán,San Miguel Panan,San Miguel Panán | Guatemala, Suchitepeque Municipio de San Miguel Panán | seat of a second-order administrative division population 2,024 | N 14° 31′ 43'' | W 91° 22′ 2'' |
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